Abstract:
Background: Polycystic ovary syndrome (PCOS) is the greatest frequent endocrine syndrome in females, giving with numerous likely mixtures of symptoms and signs and a variety of phenotypes, which might contain generative, endocrine, and metabolic modifications. PCOS is characterized by hypothalamic–pituitary– ovary axis dysfunction and anovulation ovulatory dysfunction can still occur with regular cycles and if anovulation needs to be confirmed serum progesterone levels can be measured but, unlike other causes of ovulatory disappointment that feature inadequate ovarian follicle development or repressed gonadotropin emission, PCOS typically includes androgen excess and subtle alterations in serum levels of gonadotropins and estrogens.
Objective: demonstrate and compare therapeutic effect of vitamin D; supplementation on the metabolism and endocrine parameters of polycystic ovary syndrome patients with insulin- resistance.
Subjective: The study was carried out on 86 patients, divided into 2 groups, group A treated by vitamin D supplement, while group B treated by placebo.
Results: The fasting blood sugar was significant decreased in the two studied groups. HOMA IR shows a significant decrease in the two studied groups after treatment but in group A “vitamin D supplement” decrease by a highly significant degree than the placebo group. SHBG show a significant increase in both studied groups, after treatment there was a slight increase in group A more than group B in SHBG but this increase was insignificant. Vitamin D induces the transcription of HOXA10 through vitamin D receptors. Managenent with vitamin D rises mRNA and protein appearance of HOXA10. Vitamin D too has a straight influence on the rule of HOXA10, and this has implications for fertility.
Conclusion: A significant effects of vitamin D supplementation on either metabolic or endocrine parameters in our study of PCOS women with insufficient baseline 25(OH)D concentrations.
